Piperine regulates the circadian rhythms of hepatic clock gene expressions and gut microbiota in high-fat diet-induced obese rats

作     者：Weiyun Zhang Chi-Tang Ho Wenlian Wei Jie Xiao Muwen Lu Weiyun Zhang;Chi-Tang Ho;Wenlian Wei;Jie Xiao;Muwen Lu

作者机构：Guangdong Provincial Key Laboratory of Nutraceuticals and Functional FoodsCollege of Food ScienceSouth China Agricultural UniversityGuangzhou 510642China Department of Food ScienceRutgers UniversityNew Brunswick 08901USA 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2024年第13卷第3期

页      面：1617-1627页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 083201[工学-食品科学] 

基　　金：financially supported by the Program for Guangdong Introducing Innovative and Entrepreneurial Teams (2019ZT08N291) the National Natural Science Foundation of China (31901689) the Natural Science Foundation of Guangdong Province,China (2021A1515012124)。 

主　　题：Piperine Circadian clock Obesity Gut microbiota 

摘      要：The interplay between the host circadian clock and microbiota has significant influences on host metabolism processes,and circadian desynchrony triggered by high-fat diet(HFD)is closely related to metabolic disorders.In this study,the modulatory effects of piperine(PIP)on lipid metabolism homeostasis,gut microbiota community and circadian rhythm of hepatic clock gene expressions in obese rats were investigated.The Sprague-Dawley(SD)rats were fed with normal diet(ND),HFD and HFD supplemented with PIP,respectively.After 9 weeks,rats were sacrificed with tissue and fecal samples collected for circadian analysis.Results showed that chronic PIP administration ameliorated the obesity-induced alterations in lipid metabolism and dysregulation of hepatic clock gene expressions in obese rats.The gut microbial communities studied through 16S rRNA sequencing showed that PIP ameliorated the imbalanced nicrobiota and recovered the circadian rhythm of Lactobacillaceae,Desulfovibrionaceae,Paraprevotellaceae,and Lachnospiraceae.The fecal metabolic profiles indicated that 3-dehydroshikimate,cytidine and lithocholyltaurine were altered,which were involved in the amino acid and fatty acid metabolism process.These findings could provide theoretical basis for PIP to work as functional food to alleviate the lipid metabolism disorder,circadian rhythm misalignment,and gut microbiota dysbiosis with wide applications in the food and pharmaceutic industries.