Investigation into the epidemiology,genetic characteristics,and clinical manifestations of the first monkeypox outbreak in Shenzhen,China

作     者：Jia Wan Xiaomin Zhang Jing Qu Bo Peng Dongfeng Kong Jianhua Lu Qinghua Hu Zhifeng Zhou Haiduan Lin Xiangjie Yao Yulin Fu Qing Xu Ying Lin Yan Yang Jinzhen Tang Lin Lin Huimin Li Ziquan Lv Zhen Zhang Xuan Zou Xiaolu Shi Jia Wan;Xiaomin Zhang;Jing Qu;Bo Peng;Dongfeng Kong;Jianhua Lu;Qinghua Hu;Zhifeng Zhou;Haiduan Lin;Xiangjie Yao;Yulin Fu;Qing Xu;Ying Lin;Yan Yang;Jinzhen Tang;Lin Lin;Huimin Li;Ziquan Lv;Zhen Zhang;Xuan Zou;Xiaolu Shi

作者机构：Shenzhen Center for Disease Control and PreventionShenzhen 518000China Shenzhen Futian District Center for Disease Control and PreventionShenzhen 518000China Shenzhen Longgang District Center for Disease Control and PreventionShenzhen 518000China 

出 版 物：《Biosafety and Health》 (生物安全与健康（英文）)

年 卷 期：2023年第5卷第5期

页      面：259-265页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：the Science and Technology Planning Project of Guangdong Province of China(Grant 2021 B1212030009) Sanming Project of Medicine in Shenzhen(No.SZSM202011008) Research Foundation of Shenzhen Science and Technology Emergency Key Technology Program(JSGG20220301090007009) Shenzhen Key Medical Discipline Construction Fund(SZXK064). 

主　　题：Monkeypox Epidemiology Genetic characteristics 

摘      要：This paper comprehensively analyses the first-ever monkeypox outbreak in Shenzhen,China,encompassing clinical symptomatology,therapeutic approaches,epidemiological research,and comprehensive laboratory tests,aiming to establish a robust reference for future monkeypox mitigation and management strategies.The investigation involved a thorough investigation of all identified positive cases,including extensive molecular analysis by nucleic acid detection and whole-genome sequencing of the monkeypox virus.Contact tracing and containment of the infected individuals were also undertaken.Three distinct monkeypox cases were identified in this unique outbreak,exhibiting mild and atypical clinical manifestations,primarily fever and rash.All cases were associated with a single transmission chain,primarily facilitated through close contact and homosexual behavior,indicative of a high-risk factor for monkeypox transmission.