Post-transplant malignancy:Focusing on virus-associated etiologies,pathogenesis,evidence-based management algorithms,present status of adoptive immunotherapy and future directions

作     者：Rahul Yadav Mohsen El Kossi Dawlat Belal Ajay Sharma Ahmed Halawa 

作者机构：Department of UrologyKidney Transplant and Robotic Uro-oncologyTender Palm Super Speciality HospitalLucknow 226010Uttar PradeshIndia Department of Urology and Kidney TransplantCharak Hospital and Research CentreLucknow 226003Uttar PradeshIndia Department of NephrologyDoncaster Royal InfirmaryDoncaster DN25LTUnited Kingdom Department of Nephrology and MedicineKasr El-Ainy School of MedicineCairo UniversityCairo 11562Egypt Department of Transplant SurgeryRoyal Liverpool University HospitalsLiverpool L78XPUnited Kingdom Department of TransplantationSheffield Teaching HospitalsSheffield S57AUUnited Kingdom 

出 版 物：《World Journal of Meta-Analysis》 (世界荟萃分析杂志)

年 卷 期：2023年第11卷第7期

页      面：317-339页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Post-transplant malignancy management Post-transplant virus-associated malignancy Cancer Kidney transplantation Solid organ transplantation Virus 

摘      要：Modern immunosuppression has led to a decrease in rejection rates and improved survival rates after solid organ *** the potency of immunosuppression promotes post-transplant viral infections and associated cancers by impairing immune response against viruses and cancer *** review reflects the magnitude,etiology and immunological characteristics of various virus-related post-transplant malignancies,emphasizing the need for future research.A multidisciplinary and strategic approach may serve best but overall literature evidence targeting it is ***,the authors attempted to provide a more detailed update of the literature consensus for the prevention,diagnosis,management and surveillance of post-transplant viral infections and associated malignancies,with a focus on the current role of adoptive immunotherapy and the way *** order to achieve long-term patient and graft survival as well as superior post-transplant outcomes,collaborative research on holistic care of organ recipients is imperative.