Pregnancy outcomes of four different cycle protocols for frozen embryo transfer: a large retrospective cohort study

作     者：Yue Qian Qi Wan Xiao-Qing Bu Tian Li Xiao-Jun Tang Yan Jia Qian Feng Xing-Yu Lv Xiang-Qian Meng Yin Yang Yu-Bin Ding Li-Hong Geng Min Xia Zhao-Hui Zhong Yue Qian;Qi Wan;Xiao-Qing Bu;Tian Li;Xiao-Jun Tang;Yan Jia;Qian Feng;Xing-Yu Lv;Xiang-Qian Meng;Yin Yang;Yu-Bin Ding;Li-Hong Geng;Min Xia;Zhao-Hui Zhong

作者机构：Department of EpidemiologySchool of Public Health and ManagementResearch Center for Medicine and Social DevelopmentInnovation Center for Social Risk Governance in HealthChongqing Medical UniversityChongqing 400016China Chengdu Xi'nan Gynecological HospitalChengdu 610011China Department of Gynecology and ObstetricsWest China Second HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)Ministry of EducationChengdu 610041China Department of Reproductive MedicineThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of ChinaSchool of Public Health and ManagementChongqing Medical UniversityChongqing 400016China Department of GynecologyChongqing Hospital of Traditional Chinese MedicineChongqing 4uuuzlChina. 

出 版 物：《Reproductive and Developmental Medicine》 (生殖与发育医学（英文版）)

年 卷 期：2023年第7卷第3期

页      面：135-141页

核心收录：

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：supported by the grants from Natural Science Foundation of Chongqing(Nos:cstc2019jcyj-msxmX0749,cstc2019jxjl130030,cstc2018jxjl130065) Intelligent Medicine Research Project of Chongqing Medical University(YJSZHYX202010) Sichuan Provincial Science and Technology Plan Project(2019YFSY0047)and Applied Basic Research Project in Sichuan Province(2018JY0357). 

主　　题：Clinical pregnancy rate Endometrial preparation protocols Frozen-thawed embryo transfer Live birth rate Natural cycle 

摘      要：Objective:To evaluate the pregnancy outcomes of the four endometrial preparation protocols for people undergoing frozen-thawed embryo transfer(FET),including natural cycle(NC),hormone replacement therapy cycle(HRT),gonadotropin-releasing hormone agonist artificial cycle(GAC),and ovarian stimulation cycle(OC).Methods:This retrospective cohort study enrolled 10,333 cycles of frozen embryo transfer performed at Xinan Gynecological Hospital in Sichuan,China,from January 2018 to December 2018.The patient s baseline characteristics and pregnancy outcomes were extracted from the medical record system.Pregnancy outcomes were compared among the four groups and multiple logistic regression models were used to adjust for the confounding factors.Results:After adjusting for covariates,multiple logistic regression analysis showed no statistical significance in pregnancy outcomes in the HRT group,GAC group,and OC group compared to the NC group in the entire population.The adjusted odds ratio of live birth was 0.976(95%)confidence interval[Cl](0.837-1.138)for the HRT group,0.959(95%confidence interval 0.797-1.152)for the GAC group,and 0.909(95%confidence interval 0.763-1.083)for the OC group.Conclusions:The natural protocol had comparable pregnancy outcomes compared to the other three endometrial preparation protocols in the overall FET population.More high-quality prospective randomized controlled trials are required to assess the efficacy of the four protocols and explore the optimal one.