Transient receptor potential-related risk model predicts prognosis of hepatocellular carcinoma patients

作     者：Xiao-Cai Mei Qian Chen Shi Zuo 

作者机构：Department of Hepatobiliary SurgeryAffiliated Hospital of Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina Department of Organ TransplantationAffiliated Hospital of Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2023年第15卷第12期

页      面：2064-2076页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by National Natural Science Foundation of China,No.82260535 National Natural Science Foundation of Guizhou Medical University Hospital Incubation Program,No.gyfynsfc-2022-07 

主　　题：Transient receptor potential family genes Hepatocellular carcinoma Transient receptor potential canonical type 1 Novel oncogene 

摘      要：BACKGROUND Members of the transient receptor potential(TRP)protein family shape oncogenic development,but the specific relevance of TRP-related genes in hepatocellular carcinoma(HCC)has yet to be *** To investigate the role of TRP genes in HCC,their association with HCC development and treatment was *** HCC patient gene expression and clinical data were downloaded from The Cancer Genome Atlas database,and univariate and least absolute shrinkage and selection operator Cox regression models were employed to explore the TRP-related risk *** on these analyses,clinically relevant TRP family genes were selected,and the association between the key TRP canonical type 1(TRPC1)gene and HCC patient prognosis was *** In total,28 TRP family genes were screened for clinical relevance,with multivariate analyses ultimately revealing three of these genes(TRPC1,TRP cation channel subfamily M member 2,and TRP cation channel subfamily M member 6)to be significantly associated with HCC patient prognosis(P0.05).These genes were utilized to establish a TRP-related risk *** were separated into low-and high-risk groups based on the expression of these genes,and high-risk patients exhibited a significantly poorer prognosis(P=0.001).Functional analyses highlighted pronounced differences in the immune status of patients in these two groups and associated enriched immune ***1 was identified as a candidate gene in this family worthy of further study,with HCC patients expressing higher TRPC1 levels exhibiting poorer survival ***,quantitative,immunohistochemistry,and western blot analyses revealed increased TRPC1 expression in *** These three TRP genes help determine HCC patient prognosis,providing insight into tumor immune status and immunological *** findings will help design combination therapies including immunotherapeutic and anti-TRP agents.