Gut virome:The next frontier in the treatment of necrotizing enterocolitis

作     者：Shuqin Zeng Li Zeng Panyu Yang Qu Zheng Shaopu Wang 

作者机构：Department of PediatricsKey Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)Ministry of EducationWest China Second University HospitalSichuan UniversityChengduSichuan 610041China Sichuan Jinxin Xinan Women&Children HospitalChengduSichuan 610000China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2024年第137卷第5期

页      面：562-564页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.82100590 and 82241036) the Department of Science and Technology of Sichuan Province(No.2023NSFSC0579) 

主　　题：elevated frontier treatment 

摘      要：Necrotizing enterocolitis(NEC)is a devastating gastrointestinal disease over decades,which,however,remains the leading cause of morbidity and mortality in preterm infants.^([1])Although multiple factors,including gastrointestinal tract bacterial colonization,immaturity,and formula feeding,are reported to be involved in the pathogenesis of NEC,the precise mechanisms are not well *** to the advances in metagenomic sequencing,ample evidences have illustrated the presence of gut dysbacteriosis in infants with NEC,which is characterized by an elevated abundance of Proteobacteria,reduced abundance of Firmicutes phyla,and an overall decrease in bacterial diversity,providing novel insights into NEC progression.^([1,2])Additionally,the bacterial replication rates,particularly those of Enterobacteriaceae,rapidly increase two days prior to NEC diagnosis.^([2])