Double-tract reconstruction is superior to esophagogastrostomy in controlling reflux esophagitis and enhancing quality of life after proximal gastrectomy:Results from a prospective randomized controlled clinical trial in China

作     者：Yinan Zhang Hongtao Zhang Yan Yan Ke Ji Ziyu Jia Heli Yang Biao Fan Anqiang Wang Xiaojiang Wu Ji Zhang Jiafu Ji Xin Ji Zhaode Bu Yinan Zhang;Hongtao Zhang;Yan Yan;Ke Ji;Ziyu Jia;Heli Yang;Biao Fan;Anqiang Wang;Xiaojiang Wu;Ji Zhang;Jiafu Ji;Xin Ji;Zhaode Bu

作者机构：Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Gastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China Guowen(Changchun)International HospitalChangchun 136199China State Key Laboratory of Holistic Integrative Management of Gastrointestinal CancersBeijing Key Laboratory of Carcinogenesis and Translational ResearchEndoscopy CenterPeking University Cancer Hospital&InstituteBeijing 100142China State Key Laboratory of Holistic Integrative Management of Gastrointestinal CancersBeijing Key Laboratory of Carcinogenesis and Translational ResearchGastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2023年第35卷第6期

页      面：645-659页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the Beijing Municipal Administration of Hospitals Incubating Program(No.PX2019039) 

主　　题：Double-tract reconstruction proximal gastrectomy quality of life reflux esophagitis 

摘      要：Objective:The aim of this study was to prospectively compare double-tract reconstruction(DTR)and esophagogastrostomy(EG)after proximal gastrectomy(PG)regarding the incidence of reflux esophagitis,quality of life(QOL),nutritional status and surgical ***:This study was a randomized controlled *** eligible for PG were enrolled and randomly assigned to the EG group and DTR *** characteristics of patients,parameters for surgical safety,incidence of reflux esophagitis,nutrition status and QOL were collected and compared between the two *** analysis and multivariate analysis were performed to determine the significant factors affecting the incidence of reflux esophagitis after ***:Thirty-seven patients of the EG group and 36 patients of the DTR group were *** incidence of reflux esophagitis was significantly lower in the DTR group than in the EG group(8.3%vs.32.4%,P=0.019).The DTR group demonstrated a more favorable QOL than the EG group after *** nutritional status was balanced within the EG group and the DTR *** operation time was longer in the DTR group than in the EG group(191 min vs.221 min,P=0.001),while surgical safety was similar in the two ***:Our research demonstrated that DTR is superior to EG after PG in terms of the incidence of reflux esophagitis and provides a more satisfactory QOL without increasing surgical complications or sacrificing nutritional status.