Conversion immunotherapy for deficient mismatch repair locally unresectable colon cancer:A case report

作     者：Zhen Sun He Liu Guan-Nan Zhang Yi Xiao 

作者机构：Division of Colorectal SurgeryDepartment of General SurgeryPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Gastrointestinal SurgeryThe People's Hospital of Huangdao DistrictQingdao 266400Shandong ProvinceChina 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2023年第15卷第12期

页      面：2237-2241页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by National High Level Hospital Clinical Research Funding No.2022-PUMCH-C-027 

主　　题：Colon cancer Immunotherapy Pathological complete response Case report 

摘      要：BACKGROUND Owing to the special features of biologics,deficient mismatch repair(dMMR)in patients with colon cancer has achieved little treatment efficacy from *** has shown promising results for the treatment of colon *** high response rate observed suggests a great option for patients presenting with unresectable tumors,as it allows for better oncological ***,we aimed to highlight the significant effects of immunotherapy on dMMR in colon *** SUMMARY A 54-year-old man diagnosed with locally unresectable dMMR colon cancer received preoperative immunotherapy(three cycles of pembrolizumab)and achieved a pathological complete response after *** Immunotherapy can be used as a conversion treatment for locally unresectable colon cancer with dMMR.