Application of Tranexamic Acid in Shoulder Arthroscopic Surgery:A Randomised Controlled Trial

作     者：Tian-Ci Wang Jia-Liang Guo Qiu-Ping Tian He-Ping Deng Bing Yin Zeng Xiao Bo Lu 

作者机构：Department of Orthopedic TraumaHebei Medical University Third Affiliated HospitalShijiazhuang 050051China Medical Services SectionHebei Medical University Third Affiliated HospitalShijiazhuang 050051China Department of UltrasonographyHebei Medical University Third Affiliated HospitalShijiazhuang 050051China Graduate School of Hebei Medical UniversityShijiazhuang 050011China 

出 版 物：《Chinese Medical Sciences Journal》 (中国医学科学杂志（英文版）)

年 卷 期：2023年第38卷第4期

页      面：273-278页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：tranexamic acid shoulder arthroscopic surgery visual clarity rotator cuff tear administration route 

摘      要：Objective To explore the optimal administration route of tranexamic acid(TXA)in shoulder arthroscopic *** Patients undergoing arthroscopic rotator cuff repair were randomly divided into four groups:control group(without TXA treatment),intravenous group(TXA was intravenously administered 10 minutes before surgery),irrigation group(TXA was added to the irrigation fluid during subacromial decompression and acromioplasty),and intravenous plus irrigation group(TXA was applied both intravenously and via intra-articular irrigation).The primary outcome was visual clarity assessed with visual analog scale(VAS)score,and the secondary outcomes included irrigation fluid consumption and time to subacromial decompression and acromioplasty *** There were 134 patients enrolled in the study,including 33 in the control group,35 in the intravenous group,32 in the irrigation group,and 34 in the intravenous plus irrigation *** median and interquartile range of VAS scores for the intravenous,irrigation,and intravenous plus irrigation groups were 2.70(2.50,2.86)(Z=-3.677,P=0.002),2.67(2.50,2.77)(Z=-3.058,P0.001),and 2.91(2.75,3.00)(Z=-6.634,P0.001),respectively,significantly higher than that of the control group[2.44(2.37,2.53)].Moreover,the control group consumed more irrigation fluid than the intravenous group,irrigation group,and intravenous plus irrigation group(all P0.05).The intravenous plus irrigation group consumed less irrigation fluid than either the intravenous group or the irrigation group(both P0.001).There was no difference in subacromial decompression and acromioplasty operative time among the four *** TXA applied both topically and systematically can improve intraoperative visual clarity,and the combined application is more effective.