Baseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines

作     者：Ye Peng Lin Zhang Chris K.P.Mok Jessica Y.L.Ching Shilin Zhao Matthew K.L.Wong Jie Zhu Chunke Chen Shilan Wang Shuai Yan Biyan Qin Yingzhi Liu Xi Zhang Chun Pun Cheung Pui Kuan Cheong Ka Long Ip Adrian C.H.Fung Kenneth K.Y.Wong David S.C.Hui Francis K.L.Chan Siew C.Ng Hein M.Tun Ye Peng;Lin Zhang;Chris K.P.Mok;Jessica Y.L.Ching;Shilin Zhao;Matthew K.L.Wong;Jie Zhu;Chunke Chen;Shilan Wang;Shuai Yan;Biyan Qin;Yingzhi Liu;Xi Zhang;Chun Pun Cheung;Pui Kuan Cheong;Ka Long Ip;Adrian C.H.Fung;Kenneth K.Y.Wong;David S.C.Hui;Francis K.L.Chan;Siew C.Ng;Hein M.Tun

作者机构：Microbiota I-Center(MaglC)Hong KongChina Jockey Club School of Public Health and Primary CareThe Chinese University of Hong KongHong KongChina Li Ka Shing Institute of Health SciencesFaculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and TherapeuticsThe Chinese University of Hong KongHong KongChina Department of SurgeryLKS Faculty of MedicineThe University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious DiseasesFaculty of MedicineThe Chinese University of Hong KongHong KongChina Centre for Gut Microbiota ResearchThe Chinese University of Hong KongHong KongChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第10期

页      面：5085-5095页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 10[医学] 

基　　金：The study was supported by the Health and Medical Research Fund(HMRF)Commissioned Research Grant(COVID193002)(F.K.L.C.) Enhanced start-up research grant of CUHK(H.M.T.) Hui Hoy&Chow Sin Lan Charity Fund Limited(S.C.N.) the National Research Foundation of Korea(NRF)grant funded through the Korea government(NRF-2018M3A9H4055203)(C.K.P.M.) Emergency Key Program of Guangzhou Laboratory(Grant No.EKPG22-30-6)(C.K.P.M.). 

主　　题：vaccine immunity vaccines 

摘      要：The role of gut microbiota in modulating the durability of cOVID-19 vaccine immunity is yet to be characterised.In this cohort study,we collected blood and stool samples of 121 BNT162b2 and 40 CoronaVac vaccinees at baseline,1 month,and 6 months post vaccination(p.v).Neutralisation antibody,plasma cytokine and chemokines were measured and associated with the gut microbiota and metabolome composition.