Predictive value of frailty assessment tools in patients undergoingsurgery for gastrointestinal cancer: An observational cohort study

作     者：Hui-Pin Zhang Hai-Lin Zhang Xiao-Min Zhou Guan-Jie Chen Qi-Fan Zhou Jie Tang Zi-Ye Zhu Wei Wang 

作者机构：Department of Gastrointestinal SurgeryThe Affiliated Lianyungang Hospital of Xuzhou Medical UniversityLianyungang 222061Jiangsu ProvinceChina Department of Gastrointestinal SurgeryThe First People’s Hospital of ChangzhouChangzhou 213000Jiangsu ProvinceChina Department of NursingThe Affiliated Lianyungang Hospital of Xuzhou Medical UniversityLianyungang 222061Jiangsu ProvinceChina Department of Invasive TechnologyZhongda Hospital Southeast UniversityNanjing 210003Jiangsu ProvinceChina Department of Hemopurification CenterLianyungang Clinical College of Nanjing Medical UniversityLianyungang 222061Jiangsu ProvinceChina 

出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志（英文版）（电子版）)

年 卷 期：2023年第15卷第11期

页      面：2525-2536页

核心收录：

学科分类：100218[医学-急诊医学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the Postgraduate Research&Practice Innovation Program,No.SJCX22_1293 Lianyungang City Aging Health Research Project,No.L202206. 

主　　题：Gastrointestinal cancer Frailty Assessment tools Prognostic Complication Hospital costs 

摘      要：BACKGROUND Few studies have simultaneously compared the predictive value of various frailty assessment tools for outcome measures in patients undergoing gastrointestinal cancer surgery.Therefore,it is difficult to determine which assessment tool is most relevant to the prognosis of this population.AIM To investigate the predictive value of three frailty assessment tools for patient prognosis in patients undergoing gastrointestinal cancer surgery.METHODS This single-centre,observational,prospective cohort study was conducted at the Affiliated Lianyungang Hospital of Xuzhou Medical University from August 2021 to July 2022.A total of 229 patients aged≥18 years who underwent surgery for gastrointestinal cancer were included in this study.We collected baseline data on the participants and administered three scales to assess frailty:The comprehen-sive geriatric assessment(CGA),Fried phenotype and FRAIL scale.The outcome measures were the postoperative severe complications and increased hospital RESULTS The prevalence of frailty when assessed with the CGA was 65.9%,47.6%when assessed with the Fried phenotype,and 34.9%when assessed with the FRAIL scale.Using the CGA as a reference,kappa coefficients were 0.398 for the Fried phenotype and 0.291 for the FRAIL scale(both P0.001).Postoperative severe complications and increased hospital costs were observed in 29(12.7%)and 57(24.9%)patients,respectively.Multivariate logistic analysis confirmed that the CGA was independently associated with increased hospital costs(odds ratio=2.298,95%confidence interval:1.044-5.057;P=0.039).None of the frailty assessment tools were associated with postoperative severe complications.CONCLUSION The CGA was an independent predictor of increased hospital costs in patients undergoing surgery for gastro-intestinal cancer.