Fumarate hydratase:a new checkpoint of metabolic regulation in inflammatory macrophages

作     者：Aicha Jeridi Theodore S.Kapellos Ali Onder Yildirim Aicha Jeridi;Theodore S.Kapellos;Ali Önder Yildirim

作者机构：Comprehensive Pneumology Center(CPC)Institute of Lung Health and Immunity(LHI)Member of the German Center for Lung Research(DZL)Helmholtz MunichMunichGermany Institute of Experimental PneumologyUniversity HospitalLudwig-Maximilians UniversityMünchenGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第10期

页      面：4421-4423页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：Federal Ministry of Education and Research (BMBF) [01EJ2205B] Else-Kroener-Fresenius Stiftung Deutsche Forschungsgemeinschaft (DFG) [KN 1437/2-1 | YI 94/8-1] 

主　　题：al. macrophages respiration 

摘      要：A recent article published by Hooftman et al.1 in Nature identified a crucial function for fumarate hydratase(FH)in bone marrow-derived macrophages(BMDMs).Pharmacological inhibition or genetic ablation of FH led to increased fumarate levels and downstream suppression of mitochondrial respiration implying the importance of cellular metabolic states and cytokine balance shift in innate immunity.