Advances in metabolomics of chronic obstructive pulmonary disease

作     者：Wenqian Wu Zhiwei Li Yongqiang Wang Chuan Huang Tiantian Zhang Hongmei Zhao Wenqian Wu;Zhiwei Li;Yongqiang Wang;Chuan Huang;Tiantian Zhang;Hongmei Zhao

作者机构：The State Key Laboratory of ComplexSevereand Rare DiseasesInstitute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of PathophysiologyPeking Union Medical CollegeBeijing 100005China State Key Laboratory of Respiratory Health and MultimorbidityInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Respiratory and Critical Care Medicine302 Hospital of China Guizhou Aviation Industry GroupAn ShunGuizhou 561000China Department of Thoracic SurgeryBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100005China 

出 版 物：《Chinese Medical Journal Pulmonary and Critical Care Medicine》 (呼吸与危重症医学（英文）)

年 卷 期：2023年第1卷第4期

页      面：223-230页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Metabolomics Chronic obstructive pulmonary disease Metabolite Nutrient Microbe Dietary management 

摘      要：Chronic obstructive pulmonary disease(COPD)is a chronic lung disease with limited *** is charac-terized by chronic bronchitis and emphysema,and is often accompanied by malnutrition with fatigue,muscle weakness,and an increased risk of *** the pulmonary function test is used as the gold crite-rion for diagnosing COPD,it is unable to identify early COPD or classify the subtypes,thereby impeding early intervention and the precise diagnosis of *** evidence suggests that metabolic dysfunction,such as changes in lipids,amino acids,glucose,nucleotides,and microbial metabolites in the lungs and intestine,have a great potential for diagnosing COPD in the early ***,a comprehensive summary of these metabolites and their effects on COPD is still *** review summarizes the metabolites that are changed in COPD and highlights some promising early diagnostic markers and therapeutic *** emphasize that intensified dietary management may be among the most feasible methods to improve metabolism in the body.