A self-powered biosensor based on triboelectric nanogenerator for dual-specificity bacterial detection
作者机构：State Key Laboratory of Heavy Oil ProcessingCollege of Chemistry and Chemical EngineeringChina University of Petroleum(East China)Qingdaothe People's Republic of China Institute of OceanologyChinese Academy of SciencesQingdaothe People's Republic of China School of Material Science and EngineeringChina University of Petroleum(East China)Qingdaothe People's Republic of China State Key Laboratory of Microbial TechnologyShandong UniversityQingdaothe People's Republic of China Guangxi Academy of SciencesNanningthe People's Republic of China
出 版 物：《InfoMat》 (信息材料（英文）)
年 卷 期：2024年第6卷第3期
页 面：117-130页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：National Natural Science Foundation of China,Grant/Award Number:42276216 Natural Science Foundation of Guangxi Province,Grant/Award Number:2023GXNSFDA026059
主 题：bacterial detection high specificity microbial sensor triboelectric nanogenerator wireless transmission
摘 要：Pathogenic and corrosive bacteria pose a significant risk to human health or economic *** specific,sensitive,and on-site detection of these bacteria is thus of paramount significance but remains *** inspiration from immunoassays with primary and secondary antibodies,we describe here a rational design of microbial sensor(MS)under a dualspecificity recognition strategy using Pseudomonas aeruginosa(***)as the detection *** the MS,engineered aptamers are served as the primary recognition element,while polydopamine-N-acetyl-D-galactosamine(PDA-Gal NAc)nanoparticles are employed as the secondary recognition element,which will also generate and amplify changes in the output voltage sig*** achieve self-powering capability,the MS is constructed based on a triboelectric nanogenerator(TENG)with the specific aptamers immobilized on the TENG electrode *** as-prepared MS-TENG system exhibits good stability in output performance under external forces,and high specificity toward ***,with no cross-reactivity observed.A linear relationship(R^(2)=0.995)between the output voltage and *** concentration is established,with a limit of detection estimated at around 8.7×10^(3) CFU mL^(-1).The utilization of PDA-Gal NAc nanoparticles is found to play an important role in enhancing the specific and reliability of detection,and the underlying mechanisms are further clarified by computational *** addition,the MS-TENG integrates a wireless communication module,enabling real-time monitoring of bacterial concentration on mobile *** work introduces a pioneering approach to designing self-powered smart microbial sensors with high specificity,using a double recognition strategy applicable to various bacteria beyond ***.
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