Iridium-Catalyzed Asymmetric Hydrogenation of Dialkyl Imines

作     者：Zheng Wang Xin-Yi Yang Yue Xu Qi-Lin Zhou 

作者机构：State Key Laboratory and Institute of Elemento-Organic ChemistryCollege of ChemistryFrontiers Science Center for New Organic MatterNankai UniversityTianjin 300071 

出 版 物：《CCS Chemistry》 (中国化学会会刊（英文）)

年 卷 期：2024年第6卷第4期

页      面：905-911页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Key R&D Program of China(grant no.2022YFA1504302) the National Natural Science Foundation of China(grant nos.22188101,91956000,and 92256301) the Fundamental Research Funds for the Central Universities,and the Haihe Laboratory of Sustainable Chemical Transformations 

主　　题：spiro PNP ligand iridium catalyst enantioselective hydrogenation dialkyl imines chiral amines 

摘      要：Asymmetric hydrogenation of dialkyl imines to chiral amines is difficult because the two alkyls of imines are so similar in spatial and electronic structure that chiral catalysts are difficult to distinguish between *** this study,we described an asymmetric hydrogenation of dialkyl imines by a chiral iridium catalyst containing spiro phosphine-amine-phosphine *** precisely adjusting the chiral pocket of catalyst,a highly efficient catalyst was *** this catalyst,a variety of dialkyl imines were hydrogenated to chiral amines with high yield and enantioselectivity.