A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-Ⅱ Photo-Immunotherapy of Metastatic Tumor
作者机构:College of Pharmaceutical SciencesSoochow UniversitySuzhou 215123People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM)Soochow UniversitySuzhou 215123People’s Republic of China Center of Super‑Diamond and Advanced Films(COSDAF)&Department of ChemistryCity University of Hong Kong83 Tat Chee AvenueKowloonHong Kong SARPeople’s Republic of China
出 版 物:《Nano-Micro Letters》 (纳微快报(英文版))
年 卷 期:2024年第16卷第2期
页 面:1-14页
核心收录:
学科分类:0710[理学-生物学] 1002[医学-临床医学] 08[工学] 0805[工学-材料科学与工程(可授工学、理学学位)] 100214[医学-肿瘤学] 10[医学]
基 金:The work was financially supported by the National Natural Science Foundation of China(No.52173135,22207024) Jiangsu Specially Appointed Professorship,Leading Talents of Innovation and Entrepreneurship of Gusu(ZXL2022496) the Suzhou Science and Technology Program(SKY2022039).
主 题:NIR-Ⅱconjugated polymer Photothermal Radical Nanoparticles Cancer therapy
摘 要:Massive efforts have been concentrated on the advance of eminent near-infrared(NIR) photothermal materials(PTMs) in the NIR-Ⅱ window(1000–1700 nm), especially organic PTMs because of their intrinsic biological safety compared with inorganic PTMs. However, so far, only a few NIR-Ⅱresponsive organic PTMs was explored, and their photothermal conversion efficiencies(PCEs) still remain relatively low. Herein, donor–acceptor conjugated diradical polymers with open-shell characteristics are explored for synergistically photothermal immunotherapy of metastatic tumors in the NIR-Ⅱ window. By employing side-chain regulation, the conjugated diradical polymer TTB-2 with obvious NIR-Ⅱ absorption was developed, and its nanoparticles realize a record-breaking PCE of 87.7% upon NIR-Ⅱ light illustration. In vitro and in vivo experiments demonstrate that TTB-2 nanoparticles show good tumor photoablation with navigation of photoacoustic imaging in the NIR-Ⅱ window, without any side-effect. Moreover, by combining with PD-1 antibody,the pulmonary metastasis of breast cancer is high-effectively prevented by the efficient photo-immunity effect. Thus, this study explores superior PTMs for cancer metastasis theranostics in the NIR-Ⅱ window, offering a new horizon in developing radical-characteristic NIR-Ⅱ photothermal materials.