Can the Glucose Central Control System Dysfunctions Induce Diabetes Mellitus?

作     者：Altair S. de Assis João Luiz P. da Nobrega Altair S. de Assis;João Luiz P. da Nobrega

作者机构：Cooperation Center for the Development of Children and Adolescents—CCDIA Niterói RJ Brasil 

出 版 物：《Open Journal of Endocrine and Metabolic Diseases》 (内分泌与新陈代谢疾病期刊（英文）)

年 卷 期：2023年第13卷第12期

页      面：244-255页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Brain Hypothalamus CNS—Central Nervous System Sensor Neuron Circuits Glucose Central Control System External Noxious Elements Juvenile Persistent Hyperglycemia Diabetes Mellitus Homeostasis Euglycemia 

摘      要：We study afresh how the glucose control system anomalies impact the organicity of the glucose homeostasis and build up events of persistent hyperglycemia and diabetes mellitus. We have used critically the state of art literature related to the subject, in order to cross, to compare, and to organize the relevant contents to create a logical and consistent support to the finds. We show that it is consistent to assume that persistent hyperglycemia and diabetes mellitus can have precursors not only in pancreas, but also in brain, mainly induced by noxious dysfunctions of hypothalamus sensor neurons circuits and external noxious elements, causing pancreas overload, and the consequent exhaustion—overburden.