Vitamin A injection at birth improves muscle growth in lambs

作     者：Pengkang Song Xiaoyou Chen Jiamin Zhao Qiang Li Xinrui Li Yu Wang Bo Wang Junxing Zhao Pengkang Song;Xiaoyou Chen;Jiamin Zhao;Qiang Li;Xinrui Li;Yu Wang;Bo Wang;Junxing Zhao

作者机构：College of Animal ScienceShanxi Agricultural UniversityTaiguShanxi030801China State Key Laboratory of Animal NutritionDepartment of Animal Nutrition and Feed ScienceCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2023年第14卷第3期

页      面：204-212页

核心收录：

学科分类：1002[医学-临床医学] 0905[农学-畜牧学] 0906[农学-兽医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：funded by the National Natural Science Foundation of China(31972559,31902183) the Distinguished and Excellent Young Scholar Cultivation Project of Shanxi Agricultural University(2022JQPYGC01) 

主　　题：Vitamin A Lamb Muscle Retinoic acid Myogenesis Satellite cell 

摘      要：Vitamin A and its metabolite,retinoic acid(RA)play important roles in regulating skeletal muscle *** study was conducted to investigate the effects of early intramuscular vitamin A injection on the muscle growth of lambs.A total of 16 newborn lambs were given weekly intramuscular injections of corn oil(control group,n=8)or 7,500 IU vitamin A palmitate(vitamin A group,n=8)from birth to 3 wk of age(4 shots in total).At 3 wk of age and weaning,biceps femoris muscle samples were taken to analyze the effects of vitamin A on the myogenic capacity of skeletal muscle *** lambs were slaughtered at 8 months of *** results suggest that vitamin A treatment accelerated the growth rate of lambs and increased the loin eye area(P0.05).Moreover,vitamin A upregulated the expression of PAX7(P0.05)as evidenced by myogenic gene expression and fusion *** together,neonatal intramuscular vitamin A injection promotes lamb muscle growth by promoting the myogenic potential of satellite cells.