Features of synchronous and metachronous dual primary gastric and colorectal cancer
作者机构：Department of General Surgery(Gastrointestinal Surgery)The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of General Surgery(Colorectal Surgery)The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Follow-up officeThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2023年第15卷第11期
页 面：1864-1873页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by National Natural Science Foundation of China,No.82070684 the Fundamental and Applied Basic Research Program of Guangdong Province,No.2020B151502005 the Bethune Aixikang Distinguished Surgical Fund project,No.HZB-20190528-5 China international medical foundation,No.Z-2017-24-2110 the Program of Guangdong Provincial Clinical Research Center for Digestive Diseases,No.2020B1111170004 the National Key Clinical Discipline
主 题：Synchronous Metachronous Prognosis Gastric cancer Colorectal cancer
摘 要：BACKGROUND Studies evaluating the characteristics of dual primary gastric and colorectal cancer(CRC)(DPGCC)are *** To analyze the clinicopathologic characteristics and prognosis of synchronous and metachronous cancers in patients with *** From October 2010 to August 2021,patients with DPGCC were retrospectively *** patients with DPGCC were divided into two groups(synchronous and metachronous).We compared the overall survival(OS)between the groups using Kaplan-Meier survival *** and multivariate analyses were performed using Cox’s proportional hazards model to identify the independent prognostic factors for *** Of the 76 patients with DPGCC,46 and 30 had synchronous and metachronous cancers,*** proportion of unresectable CRC in patients with synchronous cancers was higher than that in patients with metachronous cancers(28.3%vs 3.3%,P=0.015).The majority of the second primary cancers had occurred within 5 ***-Meier survival analysis showed that the patients with metachronous cancers had a better prognosis than patients with synchronous cancers(P=0.010).The patients who had undergone gastrectomy(P0.001)or CRC resection(P0.001)had a better prognosis than those who had *** the multivariate analysis,synchronous cancer[hazard ratio(HR)=6.8,95%confidence interval(95%CI):2.0-22.7,(P=0.002)]and stage III-IV gastric cancer(GC)[HR=10.0,95%CI:3.4-29.5,(P0.001)]were risk prognostic factor for OS,while patients who underwent gastrectomy was a protective prognostic factor for OS[HR=0.2,95%CI:0.1-0.6,P=0.002].CONCLUSION Regular surveillance for metachronous cancer is necessary during postoperative *** resection is the mainstay of therapy to improve the prognosis of *** prognosis appears to be influenced by the stage of GC rather than the stage of *** with synchronous cancer have a worse prognosis,and its treatment strategy is worth further exploration.
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