Neuro-bone tissue engineering:emerging mechanisms,potential strategies,and current challenges

作     者：Wenzhe Sun Bing Ye Siyue Chen Lian Zeng Hongwei Lu Yizhou Wan Qing Gao Kaifang Chen Yanzhen Qu Bin Wu Xiao Lv Xiaodong Guo Wenzhe Sun;Bing Ye;Siyue Chen;Lian Zeng;Hongwei Lu;Yizhou Wan;Qing Gao;Kaifang Chen;Yanzhen Qu;Bin Wu;Xiao Lv;Xiaodong Guo

作者机构：Department of OrthopaedicsUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2023年第11卷第4期

页      面：695-720页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.82072446,81873999,82272460,82202715,82102546,82102627) the Natural Science Foundation of Hubei Province(2021CFB277,2021CFB596) 

主　　题：metabolism mechanisms skeleton 

摘      要：The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal *** nerve endings release neurogenic factors and sense skeletal signals,which mediate bone metabolism and skeletal *** recent years,bone tissue engineering has increasingly focused on the effects of the nervous system on bone *** regeneration of bone and nerves through the use of materials or by the enhancement of endogenous neurogenic repair signals has been proven to promote functional bone ***,emerging information on the mechanisms of skeletal interoception and the central nervous system regulation of bone homeostasis provide an opportunity for advancing ***,comprehensive reviews of this topic are ***,this review provides an overview of the relationship between nerves and bone regeneration,focusing on tissue engineering *** discuss novel regulatory mechanisms and explore innovative approaches based on nerve–bone interactions for bone ***,the challenges and future prospects of this field are briefly discussed.