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Detection and Clinical Signiifcance of Circulating Microvesicles in Severe Fever with Thrombocytopenia Syndrome

Detection and Clinical Signiifcance of Circulating Microvesicles in Severe Fever with Thrombocytopenia Syndrome

作     者:Li-ping Sun Hui-yu Li Xiao-ling Yi Aime Niyonsaba Ning-fang Wang Sheng-hua Jie 

作者机构:Department of Infectious Diseases Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei Province 430022 China Center for Stem Cell Research and Application Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei Province 430022 China 

出 版 物:《国际感染病学(电子版)》 (Infection International(Electronic Edition))

年 卷 期:2013年第2卷第2期

页      面:49-54页

学科分类:1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基  金:supported by the National Nature Science Foundation of China (grant 81171638) 

主  题:Microvesicles SFTS bunyavirus Leukocytes Blood platelets 

摘      要:Objective Microvesicles (MV) released from blood cells play an important role in the progress of diseases. The purpose of this study is to detect circulating MV level of patients suffering from severe fever with thrombocytopenia syndrome (SFTS) . Methods The plasma samples of SFTS patients and healthy controls were collected. And MV from samples were isolated and MV levels were detected quantitatively. Results The results showed that the level of the circulating MV in SFTS patients was obviously higher than that of the healthy control, with statistically signiifcant difference. Further analysis revealed that MV level was relevant to the severity of SFTS patients, namely the higher the concentration of MV, the more severity of the disease. Linear correlation analysis showed that the circulating MV level in SFTS was correlated positively with leukocyte count (r=0.243, P0.05). Conclusions We demonstrated that there existed high level of circulating MV in SFTS patients, and the level of circulating MV had a close relationship with the severity of the disease and leukocyte count. Therefore, monitoring the level of circulating MV may provide a new insight for predicting the prognosis of SFTS patients.

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