Brain metabolic profile assessed by magnetic resonance spectroscopy in children with Down syndrome:Relation to intelligence quotient
作者机构：Department of PediatricsFaculty of MedicineTanta UniversityTanta 31527Al GharbiaEgypt Department of RadiologyUniversity Medical CenterDr.Sulaiman Al-Habib Medical GroupManama 26671ManamaBahrain Department of PediatricsUniversity Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671ManamaBahrain Department of PediatricsUniversity Medical CenterDr.Sulaiman Al-Habib Medical GroupManama 26671ManamaBahrain
出 版 物：《World Journal of Clinical Pediatrics》 (世界临床儿科杂志)
年 卷 期：2023年第12卷第5期
页 面：310-318页
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
主 题：Children Down syndrome Magnetic resonance spectroscopy Metabolic profile Intelligence quotient
摘 要：BACKGROUND Down syndrome(DS)is one of the most common causes of intellectual *** with DS have varying intelligence quotient(IQ)that can predict their learning *** To assess the brain metabolic profiles of children with DS and compare them to standard controls,using magnetic resonance spectroscopy(MRS)and correlating the results with *** This case-control study included 40 children with DS aged 6-15 years and 40 age and sex-matched healthy children as *** was used to evaluate ratios of choline/creatine(Cho/Cr),N-acetyl aspartic acid/creatine(NAA/Cr),and myoinositol/creatine(MI/Cr(in the frontal,temporal,and occipital lobes and basal ganglia and compared to controls and correlated with *** Children with DS showed significant reductions in NAA/Cr and MI/Cr and a non-significant reduction in Cho/Cr in frontal lobes compared to ***,we observed significant decreases in NAA/Cr,MI/Cr,and Cho/Cr in the temporal and occipital lobes and basal ganglia in children with DS compared to ***,there was a significant correlation between IQ and metabolic ratios in the brains of children with *** Brain metabolic profile could be a good predictor of IQ in children with DS.
维普期刊数据库