Adult localized Langerhans cell histiocytosis:A case report

作     者：Pan-Pan Yang Su-Ye Hu Xu-Ya Chai Xiao-Meng Shi Li-Xia Liu Ling-E Li 

作者机构：Department of DermatologyShijiazhuang TCM HospitalShijiazhuang 050051Hebei ProvinceChina Department of PathologyShijiazhuang TCM HospitalShijiazhuang 050051Hebei ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2023年第11卷第34期

页      面：8164-8169页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Traditional Chinese Medicine Research Program of Hebei Provincial Administration of Traditional Chinese Medicine No.2022465 

主　　题：Langerhans cell histiocytosis Adult Vulva Crissum S100 Case report 

摘      要：BACKGROUND Langerhans cell histiocytosis(LCH)is a rare clonal proliferative disease of Langerhans cells with unknown *** increasing number of clinicians recognize that LCH has a wide clinical spectrum and a highly varied *** rarely develop ***,we report a case of adult localized *** SUMMARY A 32-year-old woman presented with plaques and ulcers on the vulva and crissum,accompanied by pain that persisted for more than one *** examination revealed a red-infiltrating plaque with ulcerations and exudates in the vulva and *** examination revealed a diffuse infiltration of lymphocytes,eosinophilic granulocytes,and histiocytoid cells in the superficial *** histiocytoid cells showed mild atypia,partly with kidneyshaped *** examination showed that the histiocytoid cells were positive for S100 protein and CD1 and weakly positive for CD68(20%+),with a Ki-67 index of 30%.Laboratory tests did not reveal any other systemic *** patient was diagnosed with adult localized LCH and was prescribed oral prednisone(20 mg)once *** skin lesions gradually improved and are still being *** Adult localized LCH is rare and must be differentiated from other common conditions.