Palladium-catalyzed multi components oxy-aminofluorination and aminofluorination of gem-difluoroalkenes

作     者：Fen Wu Xin Li Junbiao Chang Dachang Bai Fen Wu;Xin Li;Junbiao Chang;Dachang Bai

作者机构：State Key Laboratory of Antiviral DrugsNMPA Key Laboratory for Research and Evaluation of Innovative DrugKey Laboratory of Green Chemical Media and ReactionsMinistry of EducationSchool of Chemistry and Chemical EngineeringPingyuan LaboratoryHenan Normal UniversityXinxiang 453007China State Key Laboratory of Organometallic ChemistryShanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第2期

页      面：420-425页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.82130103,U1804283,21801067) the Central Plains Scholars and Scientists Studio Fund(No.2018002) the Project funded by the Natural Science Foundation of Henan Province(Nos.202300410225,222102310562) Henan Postdoctoral Science Foundation(No.202103087) the financial support from Henan Key Laboratory of Organic Functional Molecules and Drug Innovation 

主　　题：Palladium Multi components Aminofluorination Oxy-aminofluorination C(sp^(3))-O bond cleavage 

摘      要：Organofluorine compounds are widely used in the realm of drug discovery and material ***,we developed palladium catalyzed intermolecular aminofluorination and oxy-aminofluorination of gem‑difluoroalkenes with N-fluorobenzenesulfonimide(NFSI),in which NFSI was used as the nitrogen source and *** reaction provides an efficient and straightforward synthesis route of a series ofα-trifluoromethyl benzylic ***,three/four components oxy-aminofluorination processes were realized to giveα-trifluoromethyl benzylic ether with a terminal amino group,which proceed through C(sp^(3))-O bond cleavage of easily available ether and simultaneous introduced a fluorine,an amino and an oxy substituent in one pot with excellent *** divergent reactivity not only included the incorporation of one ether molecular,but also much more challenged two ether insertion with excellent selectivity through succession C(sp^(3))-O bonds *** protocol allows for concise synthesis of high value amines with fluoroalkyl-substituents and selectively transformation of easily available ethers by high-valent palladium catalysis.