Anion cascade reactions Ⅲ:Synthesis of 3-isoquinuclidone bridged polycyclic lactams

作     者：Zhiguo Zhang Bingbing Shi Xiyang Cao Nana Ma Hao Wu Xingjie Zhang Guisheng Zhang Zhiguo Zhang;Bingbing Shi;Xiyang Cao;Nana Ma;Hao Wu;Xingjie Zhang;Guisheng Zhang

作者机构：Key Laboratory of Green Chemical Media and ReactionsMinistry of EducationCollaborative Innovation Centre of Henan Province for Green Manufacturing of Fine ChemicalsNMPA Key Laboratory for Research and Evaluation of Innovative DrugSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第2期

页      面：426-430页

核心收录：

学科分类：08[工学] 0817[工学-化学工程与技术] 081701[工学-化学工程] 

基　　金：National Natural Science Foundation of China(NSFC,Nos.21772032,21877206,and 22101074) the 111 Project(No.D17007) Excellent Youth Foundation of Henan Scientific Committee(No.222300420012) China Postdoctoral Science Foundation(No.2019M660173) the Natural Science Foundation of Henan Province(No.202300410233) Henan Key Laboratory of Organic Functional Molecules and Drug Innovation for financial support 

主　　题：Anion cascade reactions 3-Isoquinuclidone Bridged polycyclic lactams Bis-Michael addition reaction Hemiaminalization 

摘      要：Bridged polycyclic lactams are important structural units in organic functional materials,natural products,and pharmaceuticals.A flexible and efficient anion cascade reaction was developed for the preparation of bridged polycyclic lactams from readily available malonamides and 1,4‑*** highly substituted bridged polycyclic lactams were synthesized in good to excellent yields by tandem nucleophilic sequences in the presence of t BuOK in commercially available EtOH solvent at 60℃.Notably,the simple reactions can be run on a gram ***,bis-Michael addition reaction and hemiaminalization reactions are involved in the tandem transformation.