应用相敏HMQC和HSQC谱准确测定异核碳-氢偶合常数
Accurate Measurements of Heteronuclear 13C-1H Coupling Constants by Phase-sensitive HMQC and HSQC Spectra作者机构:中国科学院广州化学研究所广州510650
出 版 物:《高等学校化学学报》 (Chemical Journal of Chinese Universities)
年 卷 期:2001年第22卷第5期
页 面:863-865页
核心收录:
学科分类:07[理学] 070203[理学-原子与分子物理] 0702[理学-物理学]
主 题:HMQC HSQC 反式检测 核磁共振 异核碳-氢偶合常数 分子结构
摘 要:Phase sensitive HMQC(Heteronuclear Multiple Quantum Coherence) and HSQC(Heteronuclear Single Quantum Coherence) experiments with t 1 noise reduction are proposed for the accurate measurement of heteronuclear one bond 13 C 1H coupling constants. The resulting 2D spectra give anti phase splittings of heteronuclear one bond couplings along ω 2 dimension, so that the precision of coupling constant measurement is less subject to the residual t 1 noise. By combining use of data fitting procedure on a spectrum with enough digital resolution and signal to noise ratio, a precision of about 0 03 Hz can be achieved in the measurement of heteronuclear one bond coupling constants. The proposed method can be very useful for the study of residual dipolar couplings caused by the alignment in high magnetic field and the dynamic frequency shift caused by the cross correlation between chemical shift and spin dipolar interactions.