Visual recognition memory is related to basic expression level of NMDA receptor NR1/NR2B subtype in hippocampus and striatum of rats
Visual recognition memory is related to basic expression level of NMDA receptor NR1/NR2B subtype in hippocampus and striatum of rats作者机构：Department of Neurobiology Zhejiang University School of Medicine Hangzhou China
出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期：2005年第26卷第2期
页 面：177-180页
核心收录：
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
基 金：Project supported by Key National Basic Research Program of China(№ G2002CB-713808) Outstanding Cross-Century Faculty Grant of the Ministry of Education of China the National Natural ScienceFoundation of China(№ 30270436 and 30371638)
主 题：N-methyl-D-aspartate receptors NR1 subunit NR2B subunit Western blotting visual recognition memory
摘 要：Aim:To examine the basic expression levels of N-methyl-D-aspartate(NMDA)receptor NR 1 and NR2B subunits in six brain regions of Sprague-Dawley(SD)ratswith different visual recognition ***:Rats were tested by a novel-object-recognition model and grouped into the high and the low visual recogni-tion memory *** expression levels of NR1 and NR2B subunits in thecortex,hippocampus,striatum,amygdala,diencephalon,and olfactory bulb weremeasured by semiquantitative ***:The NR1 and NR2Bsubunit protein levels in the hippocampus of the high visual recognition memorygroup were 35.9%(P0.01)and 53.4%(P0.05)higher respectively than those inthe low *** addition,the NR2B level in the striatum in the high visualrecognition memory group was 25.0%(P0.05)higher than that in the low ***,no significant difference was found in the levels of the subunits be-tween the two groups in other brain ***:The visual recognitionmemory in rats is related to the basic expression level of NMDA receptor NR1/NR2B subtype in the hippocampus and striatum.
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