Roles of lncRNA in the diagnosis and prognosis of triple-negative breast cancer

作     者：Qiuhui YANG Yeqin FU Jiaxuan WANG Hongjian YANG Xiping ZHANG Qiuhui YANG;Yeqin FU;Jiaxuan WANG;Hongjian YANG;Xiping ZHANG

作者机构：Department of Breast SurgeryZhejiang Cancer HospitalHangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhou 310022China Postgraduate Training Base Alliance of Wenzhou Medical University(Zhejiang Cancer Hospital)Hangzhou 310022China Shanxi Medical UniversityJinzhong 030600China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2023年第24卷第12期

页      面：1123-1140页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 08[工学] 100214[医学-肿瘤学] 0836[工学-生物工程] 10[医学] 

基　　金：supported by the Zhejiang Provincial Natural Science Foundation of China(No.LBY21H160001) 

主　　题：Triple-negative breast cancer(TNBC) Long non-coding RNA(lncRNA) Diagnosis Prognosis Chemotherapy 

摘      要：Breast cancer is a malignant tumor that seriously endangers women s lives. The prognosis of breast cancer patients differs among molecular types. Compared with other subtypes, triple-negative breast cancer(TNBC) has been a research hotspot in recent years because of its high degree of malignancy, strong invasiveness, rapid progression, easy of recurrence,distant metastasis, poor prognosis, and high mortality. Many studies have found that long non-coding RNA(lncRNA) plays an important role in the occurrence, proliferation, migration, recurrence, chemotherapy resistance, and other characteristics of TNBC. Some lncRNAs are expected to become biomarkers in the diagnosis and prognosis of TNBC, and even new targets for its treatment. Based on a PubMed literature search, this review summarizes the progress in research on lncRNAs in TNBC and discusses their roles in TNBC diagnosis, prognosis, and chemotherapy with the hope of providing help for future research.