Six new coumarins from the roots of Toddalia asiatica and their anti-inflammatory activities

作     者：HE Haoxuan LI Niping FAN Yunqi HUANG Qian SONG Jianguo LV Lixia LIU Fen WANG Lei WANG Qi GU Jihong HE Haoxuan;LI Niping;FAN Yunqi;HUANG Qian;SONG Jianguo;LV Lixia;LIU Fen;WANG Lei;WANG Qi;GU Jihong

作者机构：Science and Technology Innovation CenterGuangzhou University of Chinese MedicineGuangzhou 510405China State Key Laboratory of Bioactive Molecules and Druggability AssessmentJinan UniversityGuangzhou 510632China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2023年第21卷第11期

页      面：852-858页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported financially by the National Natural Science Foundation of China(No.82104014 and 82003605) the Key Laboratory Project of Colleges and Universities in Guangdong Province(No.2019KSYS005) the Guangdong Province Science and Technology Plan International Cooperation Project(No.2020A0505100052) 

主　　题：Toddalia asiatica Coumarins Anti-inflammatory effects RAW 264.7 cells 

摘      要：We reported the discovery of six novel coumarins, toddasirins A–F ( 1 – 6 ), each endowed with modified isoprenyl or geranyl side chains, derived from the roots of Toddalia asiatica. Comprehensive structural elucidation was achieved through multispectroscopic analyses, single-crystal X-ray diffraction experiments, and advanced quantum mechanical electronic circular dichroism (ECD) calculations. Furthermore, the anti-inflammatory activity of these compounds was assessed. Notably, compounds 1 – 3 and 6 demonstrated notable inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells, with 50% inhibitory concentration (IC50) values of 3.22, 4.78, 8.90, and 4.31 μmol·L^(−1), respectively.