Dual function of fungi-derived cytokines in inflammatory bowel diseases:protection or inflammation

作     者：Niusha Sharifinejad Elaheh Mahmoudi 

作者机构：Non-Communicable Diseases Research CenterAlborz University of Medical SciencesKarajIran Department of MycologySchool of MedicineAlborz University of Medical SciencesKarajIran 

出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)

年 卷 期：2023年第11卷第1期

页      面：182-190页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：inflammatory bowel diseases IBD cytokines intestinal fungi fungi-derived cytokines 

摘      要：Inflammatory bowel disease(IBD)is an immune-mediated inflammatory condition involving both the innate and adaptive immune ***,the role of intestinal fungal flora and their downstream immune pathways has been highlighted in the pathogenesis of *** as primary immune mediators require a delicate balance for maintaining intestinal *** most cytokines have a predictable role in either amplifying or attenuating inflammation in IBD,a few cytokines have shown a dual function in the inflammatory state of the *** of these dual-faced cytokines are also involved in mucosal anti-microbial defense pathways,particularly against intestinal fungal ***,we reviewed the role of these cytokines in IBD pathogenesis to achieve a better understanding of the fungal interactions in the development of IBD.