Circulating Vitamin D and Risk of Cerebrovascular Disease:A Meta-analysis

作     者：Wei Huang Meng-Xiao Feng Yuan-Qiang Lu 

作者机构：Department of Emergency MedicineThe First Affiliated HospitalZhejiang UniversitySchool of MedicineHangzhou 310003China Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang ProvinceHangzhou 310003China 

出 版 物：《Journal of Cerebrovascular Disease》 (脑血管病电子杂志（英文）)

年 卷 期：2023年第6卷第1期

页      面：1-7页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the Key Research and Development Program of Zhejiang Province[No.2019C03076] 

主　　题：Vitamin D Cerebrovascular disease Meta-analysis,Ischemic stroke Hemorrhagic stroke 

摘      要：Objective:This scoping review aims to perform a meta-analysis to harmonize the existing results on circulating vitamin D and cerebrovascular ***:Three scientific databases,PubMed,the Cochrane Library and EMBASE,were systematically *** overall relative risk(RR)and the corresponding 95%confidence interval(CI)were calculated using a random-effects model,and sensitivity analysis and publication bias tests were ***:Of the 4,138 articles retrieved,28 studies were included in our analysis,with a cumulative sample size of 284,*** random-effects meta-analysis showed an association between low levels of vitamin D and cerebrovascular disease:RR=1.39,95%CI:1.26,*** subgroup analyses,low levels of vitamin D were associated with both ischemic stroke(RR=1.35,95%CI:1.17,1.55)and hemorrhagic stroke(RR=1.70,95%CI:1.03,2.79).The funnel plot was *** analysis showed that one literature article had a significant impact on the *** was a statistically significant correlation between low levels of vitamin D and cerebrovascular ***:Vitamin D levels are associated with both ischemic and hemorrhagic stroke.