Plant-derived squalene supplementation improves growth performance and alleviates acute oxidative stress-induced growth retardation and intestinal damage in piglets

作     者：Junquan Tian Qian Jiang Xuetai Bao Fan Yang Yuying Li Haihui Sun Kang Yao Yulong Yin Junquan Tian;Qian Jiang;Xuetai Bao;Fan Yang;Yuying Li;Haihui Sun;Kang Yao;Yulong Yin

作者机构：National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionKey Laboratory of Agro-ecological Processes in Subtropical RegionLaboratory of Animal Nutritional Physiology and Metabolic ProcessInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha410125China University of Chinese Academy of SciencesBeijing100008China College of Animal Science and TechnologyHunan Agricultural UniversityChangsha410000China Institute of Bast Fiber CropsChinese Academy of Agricultural SciencesChangsha410205China Yichun Dahaigui Life Science Co.LtdYichun336000China 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2023年第15卷第4期

页      面：386-398页

核心收录：

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学] 

基　　金：supported by the National Key R&D Plan of China(2021YFD1300400.2022YFD1300403) the National Natural Science Foundation of China(32130099) Taishan Industrial Experts Program(tscy20190121) 

主　　题：Squalene Growth performance Oxidative stress Intestinal injury Antioxidant Piglet 

摘      要：Piglets are particularly susceptible to oxidative stress,which causes inferior growth performance and intestinal ***(SQ),a natural bioactive substance enriched in shark liver oil,shows excellent antioxidant properties and can currently be obtained at a low cost from deodorizer distillate during the production of plant *** study aimed to evaluate the effects of plant-derived SQ supplementation on the growth performance of piglets and explore the beneficial roles of SQ against oxidative stress and intestinal injury in diquat-challenged *** piglets were randomly divided into five groups and fed a basal diet supplemented with SQ at 0,500,1000,or 2000 mg/kg for 5 *** oxidative stress was induced in the piglets with diquat(10 mg/kg BW)at the fourth week of the experiment,followed by a 7-d recovery *** showed that before the diquat challenge,SQ supplementation significantly improved growth performance(average daily gain and feed conversion ratio)and serum antioxidant status,and after the diquat challenge,SQ supplementation significantly mitigated diquat-induced growth arrest,intestinal villous atrophy,intestinal epithelial cell apoptosis,intestinal hyperpermeability,and deficiency of intestinal epithelial tight junction proteins(zonula occludens-1,occludin,and claudin-3).Under oxidative stress induced by diquat,SQ supplementation consistently improved the antioxidant status of the small intestine,liver,and *** vitro,SQ was shown to alleviate hydrogen peroxide(H2O2)-induced increase of the levels of intracellular reactive oxygen species and apoptosis of porcine intestinal epithelial *** together,SQ supplementation improves growth performance and effectively alleviates acute oxidative stress-induced growth retardation and intestinal injury via improving antioxidant capacity in *** findings may provide an efficient strategy for alleviating oxidative stress-induced inferior growth performance and intestinal da