Novel NIR-Ⅱfluorescent probes for biliary atresia imaging

作     者：Xiaodong Zeng Yuqin Liao Xue Qiao Ke Liang Qiusi Luo Mingbo Deng Yishen Liu Weijing Zhang Xuechuan Hong Yuling Xiao Xiaodong Zeng;Yuqin Liao;Xue Qiao;Ke Liang;Qiusi Luo;Mingbo Deng;Yishen Liu;Weijing Zhang;Xuechuan Hong;Yuling Xiao

作者机构：State Key Laboratory of VirologyDepartment of CardiologyZhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China State Key Laboratory of Drug Research&Center of PharmaceuticsShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Shandong Laboratory of Yantai Drug DiscoveryBohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China Key Laboratory of Biodiversity and Environment on the Qinghai-Tibetan PlateauMinistry of EducationSchool of Ecology and EnvironmentTibet UniversityLhasa 850000China Shenzhen Institute of Wuhan UniversityShenzhen 518057China School of PharmacyYantai UniversityYantai 264005China School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200240China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2023年第13卷第11期

页      面：4578-4590页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 10[医学] 

基　　金：partially supported by grants from the National Key R&D Program of China(2020YFA0908800) NSFC(82273796) Special Funds for Guiding Local Science and Technology Development of Central Government(XZ202202YD0021C,China) Tibet Autonomous Region COVID-19 Prevention and Control Programs for Science and Technology Development(XZ202201ZY0046G,China) Guangdong Basic and Applied Basic Research Foundation(2023A1515012649,China) Shenzhen Science and Technology Research Grant(JCYJ20220530140605012,China) Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(ZNJC202209,China) Project Funded by China Postdoctoral Science Foundation(2022M712091,China) the Fundamental Research Funds for the Central Universities。 

主　　题：Biliary atresia Fluorescence imaging Second near-infrared window Early diagnosis Hepatobiliary excretion 

摘      要：Biliary atresia is a rare infant disease that predisposes patients to liver transplantation and death if not treated in time.However,early diagnosis is challenging because the clinical manifestations and laboratory tests of biliary atresia overlap with other cholestatic diseases.Therefore,it is very important to develop a simple,safe and reliable method for the early diagnosis of biliary atresia.Herein,a novel NIR-Ⅱfluorescence probe,HZL2,with high quantum yield,excellent biocompatibility,low cytotoxicity and rapid excretion through the liver and gallbladder was developed based on the oil/water partition coefficient and permeability.A simple fecal sample after injection of HZL2 can be used to efficiently identify the success of the mouse model of biliary atresia for the first time,allowing for an early diagnosis of the disease.This study not only developed a simple and safe method for the early diagnosis of biliary atresia with great potential in clinical translation but also provides a research tool for the development of pathogenesis and therapeutic medicines for biliary atresia.