Modulation of polymerization rate of N-carboxyanhydrides in a biphasic system

作     者：Guonan Ji Xuetao Zheng Xiangdie Hou Xiao Sun Shijie Wang Xiaohong Li Jianjun Cheng Ziyuan Song Guonan Ji;Xuetao Zheng;Xiangdie Hou;Xiao Sun;Shijie Wang;Xiaohong Li;Jianjun Cheng;Ziyuan Song

作者机构：Institute of Functional Nano&Soft Materials(FUNSOM)Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China Research Center for Industries of the FutureWestlake UniversityHangzhou 310030China School of EngineeringWestlake UniversityHangzhou 310030China The Key Lab of Health Chemistry and Molecular Diagnosis of SuzhouCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第1期

页      面：326-331页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：the National Natural Science Foundation of China(No.22101194 for Z.Song and No.52233015 for J.Cheng) Natural Science Foundation of Jiangsu Province(No.BK20210733 for Z.Song) Suzhou Municipal Science and Technology Bureau(No.ZXL2021447 for Z.Song) Collaborative Innovation Center of Suzhou Nano Science&Technology,the 111 Project.,Joint International Research Laboratory of Carbon-Based Functional Materials and Devices,and Suzhou Key Laboratory of Nanotechnology and Biomedicine 

主　　题：N-Carboxyanhydrides Polypeptides Biphasic system Cooperative covalent polymerization Polymerization kinetics 

摘      要：The recent advances in accelerated polymerization of N-carboxyanhydrides (NCAs) offer an effective strategy to simplify the preparation of polypeptide materials. However, the fine-tuning of polymerization kinetics, which is critical to differentiate the main polymerization and the side reactions, remains largely unexplored. Herein we report the modulation of polymerization rate of NCA in a water/oil biphasic system. By altering the aqueous pH, the initial location of the initiators, and the pK_(a) of initiating amines, we observed the change in polymerization time from several minutes to a few hours. Due to the high interfacial activity and low pKa value, controlled polymerization was observed from multi-amine initiators even if they were initially located in the aqueous phase. This work not only improves our understanding on the biphasic polymerization mechanism, but also facilitates preparation of versatile polypeptide materials.