Comparative antimicrobial activity of Moricin(naturally produced by silk worm,Bombyx mori larvae)against clinically important pathogens
作者机构：Division of EpidemiologyICAR-Indian Veterinary Research InstituteBareilly 243122India
出 版 物：《传染病研究(英文)》 (Infectious Diseases Research)
年 卷 期：2023年第4卷第4期
页 面：24-34页
学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种]
主 题：AMPs antimicrobial susceptibility Alacligenes Escherichia Klebsiella Pasteurella Salmonella Staphylococcus Yeast and moulds
摘 要：With the emergence and spread of antimicrobial resistance(AMR)it becomes pertinent to search for an antimicrobial alternative to cater for the imminent need to control total drug-resistant(TDR)and multiple-drug-resistant(MDR)*** peptides(AMPs)have shown some promise and this study was designed to evaluate antimicrobial activity of Moricin(a naturally produced AMP by silkworm,Bombyx mori larvae)against 276 microbial strains of 83 *** two(Erwinia amylovora 1,Hafnia alvei 1)strains were classified as susceptible to Moricin at a concentration≤8μg/*** susceptibility criteria were set at MIC equivalent to≤128μg/mL then Moricin inhibited 17 *** of the Bacillus species strains and majority of the strains of Acinetobacter,Aeromonas,Enterococcus,Erwinia,Raoultella,and Serratia species were significantly(p512μg/mL)to Moricin than strains belonging to Alacligenes,Bacillus,Escherichia,Klebsiella,Pantoea,Pasteurella,Salmonella,Staphylococcus and Streptococcus *** of different bacteria not only varied significantly to Moricin but also to most of the commonly used *** susceptibility of microbes not only affected by their type but also by their source of *** study concluded that Moricin has a wide spectrum but limited potential to inhibit clinically important microbial strains belonging to different species and genera.
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