Galectin-14 promotes hepatocellular carcinoma tumor growth via enhancing heparan sulfate proteoglycan modification

作     者：Liming Gou Gang Yang Sujuan Ma Tong Ding Luan Sun Fang Liu Jin Huang Wei Gao 

作者机构：Jiangsu Key Lab of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineKey Laboratory of Human Functional Genomics of Jiangsu ProvinceNational Health Commission Key Laboratory of Antibody TechniquesSchool of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Core Laboratorythe Affiliated Sir Run Run Hospital of Nanjing Medical UniversityNanjingJiangsu 211166China Department of Gastroenterologythe Affiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangzhou Medical Center of Nanjing Medical UniversityChangzhouJiangsu 213000China 

出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2023年第37卷第6期

页      面：418-430页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：The current study was supported by the National Natural Science Foundation of China(Grant Nos 81972284 and 82273239) the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant No.22KJB310001) Nanjing Medical University Science and Technology Development Foundation(Grant Nos.NMUB-20220050 and NMUB20210006) 

主　　题：hepatocellular carcinoma galectin-14 heparan sulfate proteoglycans co-receptor 

摘      要：Hepatocellular carcinoma(HCC)is a highly heterogeneous malignancy and lacks effective ***-sequencing of different gene transcripts by comparing HCC tissues and adjacent normal tissues provides some clues for investigating the mechanisms or identifying potential targets for tumor ***,genes that are exclusively expressed in a subpopulation of HCC may not be enriched or detected through such a *** the current study,we performed a single cell-clone-based screening and identified galectin-14 as an essential molecule in the regulation of tumor *** aberrant expression of galectin-14 was significantly associated with a poor overall survival of liver cancer patients with database *** down galectin-14 inhibited the proliferation of tumor growth,whereas overexpressing galectin-14 promoted tumor growth in ***-targeted metabolomics analysis indicated that knocking down galectin-14 decreased glycometabolism;specifically that glycoside synthesis was significantly *** study found that galectin-14 promoted the expression of cell surface heparan sulfate proteoglycans(HSPGs)that functioned as co-receptors,thereby increasing the responsiveness of HCC cells to growth factors,such as epidermal growth factor and transforming growth *** conclusion,the current study identifies a novel HCC-specific molecule galectin-14,which increases the expression of cell surface HSPGs and the uptake of growth factors to promote HCC cell proliferation.