Nrf2 modulates the benefits of evening exercise in type 2 diabetes
作者机构：Faculty of Basic Clinical SciencesDepartment of Pharmacology and TherapeuticsBowen UniversityIwoNigeria Faculty of MedicineDepartment of AnesthesiologyPharmacology and TherapeuticsThe University of British ColumbiaVancouverCanada
出 版 物：《Sports Medicine and Health Science》 (运动医学与健康科学（英文）)
年 卷 期：2023年第5卷第4期
页 面：251-258页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
摘 要：Exercise has well-characterized therapeutic benefits in the management of type 2 diabetes mellitus(T2DM).Most of the beneficial effects of exercise arise from the impact of nuclear factor erythroid 2 related factor-2(Nrf2)activation of glucose ***2 is an essential controller of cellular anti-oxidative capacity and circadian *** circadian rhythm of Nrf2 is influenced by circadian genes on its expression,where the timing of exercise effects the activation of Nrf2 and the rhythmicity of Nrf2 and signaling,such that the timing of exercise has differential physiological *** in the evening has beneficial effects on diabetes management,such as lowering of blood glucose and *** mechanisms responsible for these effects have not yet been associated with the influence of exercise on the circadian rhythm of Nrf2 activity.A better understanding of exercise-induced Nrf2 activation on Nrf2 rhythm and signaling can improve our appreciation of the distinct effects of morning and evening *** review hypothesizes that activation of Nrf2 by exercise in the morning,when Nrf2 level is already at high levels,leads to hyperactivation and decrease in Nrf2 signaling,while activation of Nrf2 in the evening,when Nrf2 levels are at nadir levels,improves Nrf2 signaling and lowers blood glucose levels and increases fatty acid *** the effects of Nrf2 activators on rhythmic signaling could also provide valuable insights into the optimal timing of their application,while also holding promise for timed treatment of type 2 diabetes.
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