Enzyme-mediated proximity labeling for mapping molecular interactions

作     者：Xinrui Fan Xinwen Yan Shuo Han 

作者机构：State Key Laboratory of Molecular BiologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2023年第66卷第11期

页      面：2680-2683页

核心收录：

学科分类：0710[理学-生物学] 071011[理学-生物物理学] 07[理学] 

基　　金：supported by the National Key Research and Development Program of China(2022YFA1304503 Shanghai Municipal Science and Technology Major Project. 

主　　题：function. mapping proximity 

摘      要：The interaction between biomolecules,such as protein-protein interactions,protein-nucleic acid interactions,and protein-metabolite interactions,plays a central role in regulating cellular function.Yet sensitive detection and unbiased analysis of these interactions with high spatial and temporal resolution in living cells and organisms in situ remain challenging.Thus,the development and application of novel tools for molecular interaction mapping will contribute significantly to our understanding of many key biological processes.