Organic dye assemblies with aggregation-induced photophysical changes and their bio-applications
作者机构：State Key Laboratory of Chemical Resource EngineeringBeijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijingChina
出 版 物：《Aggregate》 (聚集体(英文))
年 卷 期：2021年第2卷第4期
页 面：57-71页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 070303[理学-有机化学] 0703[理学-化学]
基 金：National Natural Science Foundation of China,Grant/Award Numbers:51903014,21774007 Beijing Natural Science Foundation,Grant/Award Number:2202043 China Postdoctoral Science Foundation,Grant/Award Numbers:2020M680310,2020M680309
主 题：aggregation-induced photophysical changes fluorescence imaging organic dye assemblies phosphorescence photodynamic therapy photothermal therapy
摘 要：Phototheranostics provide a safe,effective,and noninvasive way for the diagnosis and treatment of contemporary diseases,and organic dyes play a vital *** example,chemical modification endowed dyes with powerful reactive oxygen species or heat generation ability,favoring for photodynamic therapy and photoacoustic(PA)imaging guided photothermal therapy(PTT)of serious ***,photophysical properties manipulation of dyes has become the focus in current dye chemistry *** development of aggregate science has made great effort to solve this *** recent years,a large number of studies have focused on molecular aggregation behavior and its effect on photophysical *** most famous example is the discovery of aggregation-induced emission(AIE)*** on AIE theory,more theories for revealing the relationship between molecular aggregation behavior and photophysical properties were proposed and *** photophysical property changes caused by dye aggregation have become a unique discipline,guiding the development of molecular science and material *** the help of molecular self-assembly,controllable aggregation of dyes can be realized,and stable nano-theranostic reagents can be ***,constructing dye assemblies with various photophysical properties will greatly reduce the cost of theranostic reagents,thus,expanding biomedical applications of organic ***,this review focuses on the photophysical characteristic changes caused by dye aggregation and their biological applications including,fluorescence/phosphorescence/PA imaging as well as photodynamic and *** review will provide guidance for the design of organic dyes,the development of controllable aggregation methods,and the construction of multifunctional phototheranostic reagents.
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