Paclitaxel Prodrug Nanomedicine for Potential CT-imaging Guided Breast Cancer Therapy

作     者：Jia-Wei Chen Yi Shen Qing-Song Yu Zhi-Hua Gan Jia-Wei Chen;Yi Shen;Qing-Song Yu;Zhi-Hua Gan

作者机构：State Key Laboratory of Organic-Inorganic Composite MaterialsBeijing Laboratory of Biomedical MaterialsBeijing Advanced Innovation Center for Soft Matter Science and EngineeringCollege of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing 100029China 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学(英文版))

年 卷 期：2023年第41卷第11期

页      面：1747-1759,I0008页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：the National Natural Science Foundation of China(Nos.51973014,52033001 and 21774008) the long-term subsidy mechanism from the Ministry of Finance and the Ministry of Education of PRC for BUCT the Fundamental Research Funds for the Central Universities of China(Nos.BUCTRC201912,XK1701 and XK18028)。 

主　　题：CT imaging Paclitaxel Prodrug GSH responsiveness Polymeric nanoparticles 

摘      要：Nanotheranostics,which combine the therapeutic and diagnostic functions in one integrated system,have received extensive attentions in cancer treatments because they enable non-invasive diagnosis,tumor-targeted drug delivery,and real-time monitoring of therapeutic response.However,due to the high systemic toxicity of commonly used chemotherapeutics,current treatment still has limitations.Herein,to simultaneously achieve safe cancer therapy and therapeutic response monitoring,an iodinated prodrug strategy was proposed.2,3,5-Triiodobenzoic acid(TIBA)was used to modify both paclitaxel(PTX)and the polymeric vehicle,so that the encapsulation efficiency of PTX could be increased and the systemic toxicity could be reduced.As-prepared prodrug nanoparticles could accumulate passively in the tumor site and promptly release loaded drugs in response to the overexpressed GSH in cancer cells,which then caused efficient cell cycle arrest and apoptosis like that of the parent PTX.With this rational design,safe and efficient antitumor therapy and real-time computer tomography(CT)imaging could be simultaneously realized,facilitating potential CT imaging-guided therapy of metastatic breast cancer.