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文献详情 >Progress in oncolytic viruses ... 收藏

Progress in oncolytic viruses modified with nanomaterials for intravenous application

作     者:Liting Chen Zhijun Ma Chen Xu Youbang Xie Defang Ouyang Shuhui Song Xiao Zhao Funan Liu Liting Chen;Zhijun Ma;Chen Xu;Youbang Xie;Defang Ouyang;Shuhui Song;Xiao Zhao;Funan Liu

作者机构:Department of Surgical Oncology and General SurgeryKey Laboratory of Precision Diagnosis and Treatment of Gastrointestinal TumorsMinistry of EducationThe First Affiliated Hospital of China Medical UniversityShenyang 110001China Phase IClinical Trials CenterMinistry of EducationThe First Affiliated Hospital of China Medical UniversityShenyang 110102China CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBejing 100190China Department of General SurgeryPanjin People's HospitalPanjin 124221China Department of Hematology and RheumatologyQinghai Provincial People's HospitalXining 810007China State Key Laboratory of Quality Research in Chinese MedicineInstitute of Chinese Medical Sciences(ICMS)University of MacaoMacao 999078China Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBejing 100049China IGDB-NCNST Joint Research CenterInstitute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China 

出 版 物:《Cancer Biology & Medicine》 (癌症生物学与医学(英文版))

年 卷 期:2023年第20卷第11期

页      面:830-855页

核心收录:

学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基  金:supported by grants from the National Key R&D Program of China(Grant Nos.2021YFA0909900,X.Z 2022YFC2403401,F.L.) the National Natural Science Foundation of China(Grant Nos.32222045 and 32171384,X.Z 82073368,F.L.) the Liaoning Revitalization Talents Program(Grant No.XLYC2007071,F.L.) the Top-notch Talents Project of 2022“Kunlun Yingcai Advanced Innovation and Entrepreneurship”in Qinghai Province(Y.X.) 

主  题:Oncolytic virus nanomaterials drug delivery tumor treatment intravenous application 

摘      要:In oncolytic virus(OV)therapy,a critical component of tumor immunotherapy,viruses selectively infect,replicate within,and eventually destroy tumor ***,this therapy activates immune responses and mobilizes immune cells,thereby eliminating residual or distant cancer ***,because of OVs’high immunogenicity and immune clearance during circulation,their clinical applications are currently limited to intratumoral injections,and their use is severely *** recent years,numerous studies have used nanomaterials to modify OVs to decrease virulence and increase safety for intravenous *** most commonly used nanomaterials for modifying OVs are liposomes,polymers,and albumin,because of their biosafety,practicability,and *** aim of this review is to summarize progress in the use of these nanomaterials in preclinical experiments to modify OVs and to discuss the challenges encountered from basic research to clinical application.

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