Advance of tolerance engineering on microbes for industrial production
作者机构：State Key Laboratory of Materials-Oriented Chemical EngineeringCollege of Biotechnology and Pharmaceutical EngineeringNanjing Tech UniversityNanjing211816JiangsuChina Petrochemical Research Institute of PetroChina Co.Ltd.Beijing102206China
出 版 物：《Synthetic and Systems Biotechnology》 (合成和系统生物技术（英文）)
年 卷 期：2023年第8卷第4期
页 面：697-707页
核心收录：
学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 07[理学] 0836[工学-生物工程] 071005[理学-微生物学] 10[医学]
基 金：supported by the National Key R&D Program of China(2021YFC2100800) Research and Development Program of PetroChina(21-LH-38-05)
主 题：Tolerance engineering Stress condition Industrial microbe Metabolism engineering Synthetic biology
摘 要：Industrial microbes have become the core of biological manufacturing,which utilized as the cell factory for production of plenty of chemicals,fuels and ***,the challenge that the extreme stress conditions exist in production is unavoidable for cell ***,to enhance robustness of the chassis cell lays the foundation for development of ***,the researches on cell tolerance covered various aspects,involving reshaping regulatory network,cell membrane modification and other stress *** fact,the strategies employed to improve cell robustness could be summarized into two directions,irrational engineering and rational *** this review,the metabolic engineering technologies on enhancement of microbe tolerance to industrial conditions are ***,the novel thoughts emerged with the development of biological instruments and synthetic biology are discussed.
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