Are herbal sRNAs really novel precision medicines?

作     者：Shanfa Lu 

作者机构：Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China 

出 版 物：《Science China(Life Sciences)》 (中国科学(生命科学英文版))

年 卷 期：2023年第66卷第11期

页      面：2688-2691页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 0710[理学-生物学] 10[医学] 

主　　题：herbal intake really 

摘      要：Dear Editor,In 2012,Zhang et al.(2012)published an interesting and widely cited article in Cell Research.They reported that exogenous plant miR168a could enter mammals through oral food intake to regulate the expression of mammalian LDLRAP1 gene.From then on,cross-kingdom regulation of diet-derived plant miRNAs has generated substantial interest and attracted media to report.Although there is evidence to support this point of view,the authenticity of cross-kingdom regulation of plant miRNAs has been widely questioned.In 2019,Science China Life Sciences published a special topic entitled“Herbal small RNA,novel precision medicine from Mother Nature,in which the authors tried to demonstrate an idea that herbal sRNAs are novel precision medicines.This is a thought further than cross-kingdom regulation of sRNAs.However,are herbal sRNAs really novel precision medicines?