Is there a potential of circulating miRNAs as biomarkers in rheumatic diseases?

作     者：Klára Prajzlerová Ladislav Senolt Mária Filková Klára Prajzlerová;Ladislav Šenolt;Mária Filková

作者机构：Institute of RheumatologyPrague 12800Czech Republic Department of RheumatologyFirst Faculty of MedicineCharles UniversityPrague 12800Czech Republic 

出 版 物：《Genes & Diseases》 (基因与疾病(英文))

年 卷 期：2023年第10卷第4期

页      面：1263-1278页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by a project of the Ministry of Health of the Czech Republic(MHCR)for conceptual research development(No.023728) research project of SVV(No.260523)。 

主　　题：Biomarker Diagnosis miRNA Rheumatic diseases Therapy 

摘      要：t MicroRNAs(miRNAs)are small non-coding single-stranded RNAs of about 22 nucle-otides in length that act as post-transcriptional regulators of gene expression.Depending on the complementarity between miRNA and target mRNA,cleavage,destabilization,or transla-tional suppression of mRNA occurs within the RISC(RNA-induced silencing complex).As gene expression regulators,miRNAs are involved in a variety of biological functions.Dysregulation of miRNAs and their target genes contribute to the pathophysiology of many diseases,including autoimmune and inflammatory disorders.MiRNAs are also present extracellularly in their sta-ble form in body fluids.Their incorporation into membrane vesicles or protein complexes with Ago2,HDL,or nucleophosmin 1 protects them against RNases.Cell-free miRNAs can be deliv-ered to another cell in vitro and maintain their functional potential.Therefore,miRNAs can be considered mediators of intercellular communication.The remarkable stability of cell-free miRNAs and their accessibility in body fluid makes them potential diagnostic or prognostic bio-markers and potential therapeutic targets.Here we provide an overview of the potential role of circulating miRNAs as biomarkers of disease activity,therapeutic response,or diagnosis in rheumatic diseases.Many circulating miRNAs reflect their involvement in the pathogenesis,while for plenty,their pathogenetic mechanisms remain to be explored.Several miRNAs described as biomarkers were also shown to be of therapeutic potential,and some miRNAs arealready tested in clinical trials.