A trans-ortho asymmetrically di-strapped metalloporphyrin integrating three key structural features of ligand in heme

作     者：Qiuhua Liu Junhao Gao Yusheng Zhang Xin Liu Xi Zhang Qin Lin Wennan Zeng Zaichun Zhou Qiuhua Liu;Junhao Gao;Yusheng Zhang;Xin Liu;Xi Zhang;Qin Lin;Wennan Zeng;Zaichun Zhou

作者机构：Key Laboratory of Theoretical Organic Chemistry and Functional MoleculesMinistry of Education School of Chemistry and Chemical EngineeringHunan University of Science and TechnologyXiangtan 411201China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第10期

页      面：140-145页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the Institute of Elemento-organic Chemistry,Nankai University and the Scientific Research Fund of Hunan Provincial Education Department(No.20A195) Hunan Provincial Natural Science Foundation of China(No.2020JJ4292) the Science and Technology innovation Program of Hunan Province(No.2021RC5028). 

主　　题：Supramolecular effect Heme analog Pocket effect Axial ligation Ring distortion 

摘      要：Heme responsible for the dioxygen fixation,transport and conversion is a metalloporphyrin complex highly dependent on its diverse geometry of ligand.In this work,a trans-ortho-di-strapped zinc porphyrin with dome-like deformation was synthesized by thermodynamically controlling the formation of transprecursor of porphyrinogen.Its single-crystal structure demonstrated that the asymmetric treatment of porphyrin achieves three goals of creating two secondary coordination sphere(SCS)bulks,maintaining a unique dome deformation,and making atomic out-of-plane deviation.In this way,this metallic complex integrates at least three key features of the pocket structure,the differentiated axial ligations,and the ring distortion,making it an ideal heme analog.