针刺治疗偏头痛的效应机制研究:来自脑影像研究的证据(Ⅰ)

作     者：刘国韵 陈懿超 曹子敏 石安琪 许璐凡 李芷君 杨泽秋 闫超群 王军 Guo-yun LIU;Yi-chao CHEN;Zi-min CAO;An-qi SHI;Lu-fan XU;Zhi-jun LI;Ze-qiu YANG;Chao-qun YAN;Jun WANG

作者机构：北京中医药大学东直门医院针灸科北京100700 

出 版 物：《World Journal of Acupuncture-Moxibustion》 (世界针灸杂志（英文版）)

年 卷 期：2024年第34卷第1期

页      面：16-23页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1005[医学-中医学] 1002[医学-临床医学] 100512[医学-针灸推拿学] 10[医学] 

基　　金：Supported by National Natural Science Foundation of China Youth Fund:82004197 Department of Science and Technology,National Administration of Traditional Chinese Medicine:GZY-KJS-2022-029 The fifth batch of national research and training programs for clinical talents of traditional Chinese medicine,Project for new teachers of Beijing University of Chinese Medicine:2020-JYB-XJSJJ-045 

主　　题：Migraine Acupuncture Gray matter Voxel-based morphometry Functional connectivity Magnetic resonance imaging 

摘      要：Objective:Magnetic resonance imaging(MRI)studies have demonstrated anatomical and functional alterations of brain regions in patients with migraine,and the efficacy of acupuncture for migraine could regulate these abnormal ***,its pathogenesis remains ambiguous,and inconsistent results have been *** purpose of this study was to explore abnormal structural and functional alterations in patients with migraine using voxel-based morphometry(VBM)analysis and a seed-based functional connectivity(FC)approach and to provide a basis for future ***:The study recruited 34 patients with migraine and 38 healthy controls who underwent structural and resting-state functional magnetic resonance imaging(fMRI).VBM was evaluated across the whole brain,and group differences in the gray matter(GM)were *** significantly altered GM volumes considered as the seeding area were further calculated for the FC of the whole *** correlation between structural or functional changes of the brain and clinical features was also ***:Patients with migraine manifested higher GM volumes in the left occipital lobe than healthy ***-based analyses demonstrated reduced FC between the left occipital lobe and right inferior frontal gyrus,extending to the anterior cingulate cortex(ACC)and right *** FC in the left ACC was positively correlated with visual analog scale(VAS)and self-rating anxiety scale(SAS).