Genetic characterizations and molecular epidemiology of human echovirus 30 isolated from Ningxia,China

作     者：Fang Yuan Xinfeng Wei Xueping Ma Jiangtao Ma Xuemin Ma Xiaoqiang Sun Min Cao Juan Zhou Wei Zhang Hui Chen Rui Wang Jichen Li Qiang Sun 

作者机构：Ningxia Hui Autonomous Region Center for Disease Control and PreventionYinchuan 750004China Ningxia Hui Autonomous Region People's HospitalYinchuan 750021China National Laboratory for PoliomyelitisWHO WPRO Regional Polio Reference LaboratoryNational Key Laboratory for TraceabilityEarly Warning and Intlligent Decision of Infectious DiseasesNational Health Commission Key Laboratory for BiosafetyNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China 

出 版 物：《Biosafety and Health》 (生物安全与健康（英文）)

年 卷 期：2023年第5卷第6期

页      面：346-354页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported by the Science and Natural Science of Ningxia (Grant No.2021AAC03415) the Science and Natural Science of China (Grant No.81960607) Science and Natural Science of Ningxia (Grant No.2022AAC03708) the National Key Research and Development Program of China (Project No.2021YFC2302003) 

主　　题：Echovirus 30(E30) Complete genome sequence Molecular epidemiology 

摘      要：In October 2017,a small outbreak of echovirus 30(E30)associated with aseptic meningitis in nine cases occurred at a primary school in the Ningxia Hui Autonomous *** year,we observed a significant increase in E30 levels in an acute flaccid paralysis(AFP)case surveillance *** investigate their phylogenetic relationships,we determined the whole genomic sequences of 12 strains isolated from aseptic meningitis cases,AFP cases,and healthy *** found that the E30 strains circulating in Ningxia belong to two lineages(H and J).The strains isolated in 2010,2012,and 2016 belonged to the H *** 2017,a new lineage,J,emerged as the dominant *** trees were constructed based on the whole genome andP1,P2,andP3 regions;clustering with other types of enterovirus species B was found,suggesting that recombination events had *** recombination sites were mainly in regions2B,2C,*** study confirmed that the E30 strains in Ningxia in 2010,2012,and 2016 had different recombination patterns and were recombined with different *** 2017 epidemic E30 originated from another new lineage with a complex recombination pattern and formed an independent transmission chain in Ningxia.