Medin synergized with vascular amyloid-beta deposits accelerates cognitive decline in Alzheimer's disease:a potential biomarker

作     者：Xiao Ge Li Li Chunming Xie Xiao Ge;Li Li;Chunming Xie

作者机构：Department of NeurologyAffiliated Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina Center of Health ManagementAffiliated Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina Institute of NeuropsychiatryAffiliated Zhongda HospitalSoutheast UniversityNanjingJiangsu ProvinceChina The Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjingJiangsu ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第7期

页      面：1414-1414页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：supported by the Science and Technology Innovation 2030-Major Projects,No.2022ZD021 1 600 the National Natural Science Foundation of China,Nos.82271574 and82071204 (all to CX) 

主　　题：Alzheimer amyloid perfusion 

摘      要：Brain vascular dysfunction in Alzheimer s disease(AD) pathogenesis has become increasingly clea *** evidence shows that damaged vascular,including large or small vessels and even neurovascular unit,may accelerate the neuropathological process of AD via disrupting brain hypoperfusion,aberrant angiogenesis,and neuroinflammatory response,***,vascular dysfunction makes a substantially contribution to the cognitive decline of AD patients.