Clinical Epidemiology,Illness Profiles,and the Implication of COVID-19 Before and After the Nationwide Omicron Outbreak During the Winter of 2022

作     者：Yuming Guo Zhe Xu Wen-Xin Wang Cheng Zhen Jinhua Hu Jinsong Mu Chengcheng Ji Xin Yuan Ruonan Xu Lei Huang Lei Shi Fanping Meng Junliang Fu Shuangnan Zhou Siyu Wang Fengyi Li Bo Tu Dawei Zhang Huihuang Huang Yufeng Mao Wen Xu Chao Zhang Xiuying Mu Jun Zhao Bo Jin Haibin Su Yinying Lu Yongqian Cheng Dong Ji Shaoli You Jinghui Dong Changchun Liu Mengmeng Zhang Yuanyuan Li Tianjun Jiang Yonggang Li Fu-Sheng Wang Yuming Guo;Zhe Xu;Wen-Xin Wang;Cheng Zhen;Jinhua Hu;Jinsong Mu;Chengcheng Ji;Xin Yuan;Ruonan Xu;Lei Huang;Lei Shi;Fanping Meng;Junliang Fu;Shuangnan Zhou;Siyu Wang;Fengyi Li;Bo Tu;Dawei Zhang;Huihuang Huang;Yufeng Mao;Wen Xu;Chao Zhang;Xiuying Mu;Jun Zhao;Bo Jin;Haibin Su;Yinying Lu;Yongqian Cheng;Dong Ji;Shaoli You;Jinghui Dong;Changchun Liu;Mengmeng Zhang;Yuanyuan Li;Tianjun Jiang;Yonggang Li;Fu-Sheng Wang

作者机构：Senior Department of Infectious Diseasesthe Fifth Medical Center of Chinese People's Liberation Army(PLA)General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Senior Department of Hepatologythe Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Institute of Intensive Care Unitthe Fifth Medical Center of Chinese PLA HospitalBeijing 100039China Comprehensive Liver Cancerthe Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Geriatricsthe Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Radiologythe Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China 

出 版 物：《Infectious Diseases & Immunity》 (感染性疾病与免疫（英文）)

年 卷 期：2023年第3卷第4期

页      面：176-185页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(82370019) the Emergency Key Program of Guangzhou Laboratory(EKPG21-30-4) the National Key Research and Development Plan(2022YFC2304404,2022YFC2304803) the Military Emergency Research Project on COVID-19(BWS20J006) 

主　　题：Beijing COVID-19 Disease severity Elderly Nucleic acid conversion Omicron variant 

摘      要：*** this study,we aimed to investigate the clinical characteristics and outcomes of patients with coronavirus disease 2019(COVID-19)in the Beijing ***:In this retrospective study,we enrolled inpatients admitted for COVID-19 in the Fifth Medical Center of Chinese PLA General Hospital in Beijing between November 10,2022,and January 30,*** and clinical features and treatment outcomeswere comprehensively *** used logistic regression and linear regression analyses to explore the risk factors associated with disease severity and time of nucleic acid conversion,***:A total of 1010 hospitalized patients with COVID-19 were *** median age was 43.0 years(interquartile range,28.0–63.0),and patients aged7 pg/mL,lactic dehydrogenase level245 U/L,cough,and fever at ***≥80 years and chronic lung diseasewere independent risk factors in the nonmild group in elderly *** addition,the duration for nucleic acid to turn negativewas approximately 5.0 d(interquartile range,3.0–7.0).Prolonged time of nucleic acid conversion was associated with age≥60 years,serum urea nitrogen level8