The function and mechanism of lactate and lactylation in tumor metabolism and microenvironment
作者机构：Department of PathologyAffiliated Hospital of Guilin Medical UniversityGuilinGuangxi 541001China Hunan Key Laboratory of Cancer MetabolismHunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunan 410013China Laboratory of Genetics and MetabolismMaternal and Child Health Hospital of Guangxi Zhuang Autonomous RegionGuangxi Birth Defects Research and Prevention InstituteNanningGuangxi 530003China
出 版 物：《Genes & Diseases》 (基因与疾病(英文))
年 卷 期：2023年第10卷第5期
页 面：2029-2037页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the National Natural Science Foundation of China(No.82060042) Guangxi Natural ScienceFoundation(China)(No.2020GXNSFBA297082) Guangxi Science and Technology Program Project(China)(No.AD19245005) The Basic Ability Enhancement Program for Young and Middle-aged Teachers of Guangxi(China)(No.2020KY12017).
主 题：Epigenetic regulation Lactate Lactylation Microenvironment Tumorigenesis
摘 要：Lactate is an end product of glycolysis.Owing to the lactate shuttle concept introduced in the early 1980s,increasing researchers indicate lactate as a critical energy source for mitochondrial respiration and as a precursor of gluconeogenesis.Lactate also acts as a multifunctional signaling molecule through receptors expressed in various cells,resulting in diverse biological consequences including decreased lipolysis,immune regulation,and anti-inflammation wound healing,and enhanced exercise performance in association with the gut microbiome.Furthermore,increasing evidence reveals that lactate contributes to epigenetic gene regulation by lactylating lysine residues of histones,which accounts for its key role in immune modulation and maintenance of homeostasis.Here,we summarize the function and mechanism of lactate and lactylation in tumor metabolism and microenvironment.
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